Tretinoin Cream 0.1 In Pakistan Tretinoin Wrinkle Cream 0.1% contains the highest available concentration of tretinoin, the active ingredient most prescribed by dermatologists to treat wrinkles, fine lines, discoloration, and signs of premature aging. Tretinoin is widely recognized in skincare as one of the most powerful and effective skin treatments available and is a retinoid that increases collagen production and speeds up the skin’s natural renewal process.